data test

X-linked juvenile retinoschisis (XLRS) is a hereditary retinal dystrophy, caused by mutations in the RS1 gene which encodes the secreted protein retinoschisin. In recent years, several molecules have been proposed to interact with retinoschisin, including the retinal Na/K-ATPase, L-voltage gated Ca2+ channels, and specific sugars. We recently showed that...

Mean fluorescence intensity (MFI) from total cell population, calibrated against non-mutant ATP1B2. Given is the mean +/- SD of 3 (patch II region 4 T240A and S) or 4 (other patch II mutants) independent experiments. Neg. control: untransfected cells.

Amino acid (aa) positions and sequences of the each four regions building the predicted protein-protein-interfaces patch I and patch II of ATP1B2 as well as corresponding aa sequences in ATP1B1.

Mean fluorescence intensity (MFI) from total cell population, calibrated against non-mutant ATP1B2. Given is the mean +/- SD of 3 independent experiments. Neg. control: untransfected cells.

Comparison of median scores of the first and second edition of clinical practice guidelines (n = 64).

Comparison between pre- and post-2008 groups in terms of median scores of clinical practice guidelines for patients (n = 22).

BackgroundClinical practice guidelines (CPGs) are representative methods for promoting the standardization of healthcare and improvement of its quality. Few studies have investigated changes in the quality of CPGs published in a country over time. Our aim was to investigate changes in the quality of CPGs over time in the context of the available...

Characteristics of evaluated clinical practice guidelines.

Characteristics of TMC patientsa and non -TMC patientsa.

The predicted change in the probability of being in each of HCU quarters following each additional telephone-based consultation.

Annualized healthcare utilization of TMC patientsa before and after first consultation.

Multivariable model of total annual health care costs of TMC patientsa (n = 107).

FindingsHere, we demonstrate that OP2113 (5-(4-Methoxyphenyl)-3H-1,2-dithiole-3-thione, CAS 532-11-6), synthesized and used as a drug since 1696, does not act as an unspecific antioxidant molecule (i.e., as a radical scavenger) but unexpectedly decreases mitochondrial reactive oxygen species (ROS/H2O2) production by acting as a specific inhibitor of ROS...

Regression models of the relationship between somatic instability (SI) in DNA observed in blood and saliva and the estimated progenitor allele length in blood (ePAL) and the age at sampling (Ages).

Regression models of the relationship between age at onset (Ageo) and the progenitor allele length (ePAL) estimated from two different DNA tissue sources of the same DM1 patient.

Mean methylation percentage in blood and saliva of congenital cases within two CTCF binding sites.

Genotype-to-phenotype correlation studies in myotonic dystrophy type 1 (DM1) have been confounded by the age-dependent, tissue-specific and expansion-biased features of somatic mosaicism of the expanded CTG repeat. Previously, we showed that by controlling for the confounding effects of somatic instability to estimate the progenitor allele CTG length in...

Although alkynes have been extensively exploited in [2 + 2 + 2] cycloadditions with nitriles to form N-heterocyclic aromatics, the “alkyne-like” metal–carbon triple bond has never been used in [2 + 2 + 2] cycloadditions with nitriles. We demonstrate the synthesis of the first metallapyrazine through [2 + 2 + 2] cycloaddition reactions of a metal–carbyne...

The synthesis and characterization of an analog of the Xantphos ligand that is geometrically incapable of coordination of the xanthene bridging oxygen atom is reported. This new ligand, XL-Xantphos, ((9,9-dimethyl-9H-xanthene-4,5-diyl)­bis­(4,1-phenylene))­bis­(diphenylphosphane), was studied in homogeneous, catalytic reactions for comparison with...

Referenzzustände bis 1990 für 61 Wald- und Forstökosystemtypen in Deutschland zur Beurteilung der ökologischen Integrität. Diese enthalten jeweils ein Datenblatt des Referenzzustandes mit Angaben zur Lebensraumfunktion, Netto-Primärfunktion, Kohlenstoffspeicherung, Nährstofffluss, Wasserfluss und Anpassungsfähigkeit an veränderliche Umweltbedingungen,...